San Francisco 49ers head coach Kyle Shanahan provided injury updates on Wednesday as the team prepares for Sunday's game against the Seattle Seahawks. Neither tight end George Kittle nor defensive end Nick Bosa will participate in Wednesday's practice.

Unsurprisingly at this early part of the week, the San Francisco 49ers are playing it safe with their stars.Speaking before Wednesday's practice and revealing their preliminary injury report, head coach Kyle Shanahan revealed both George Kittle (hamstring) and Nick Bosa (hip) would miss the opening session of their preparations for Sunday's clash with the Seattle Seahawks.

After Nick Bosa played through the most painful injury of his six-season career last week, the All-Pro pass rusher isn’t sure he’ll be able to do it again when the San Francisco 49ers host the Seahawks on Sunday.

The San Francisco 49ers are preparing for their Week 11 contest against the Seattle Seahawks on Sunday at Levi's Stadium in Santa Clara, California.

San Francisco 49ers defensive end Nick Bosa had his worst game of the season Sunday against the Buccaneers. Turns out he was playing through an extremely painful hip injury that still bothers him -- he sat out Wednesday's practice because of it.

Kyle Shanahan said the 49ers are being smart with George Kittle, and cited Nick Bosa practicing through injury last week.

Nick Bosa wasn't at his best on Sunday against the Tampa Bay Buccaneers, and it showed. While the San Francisco 49ers defensive end managed to record a sack, he logged only three pressures—his lowest single-game total since Week 5.